Professor Jeremy Robertson

Position

Professor of Chemistry and Tutorial Fellow in Organic Chemistry

Qualifications

MA, DPhil (both from Oxford)

Academic Background

Undergraduate in Chemistry at Oxford (1983-1987)

DPhil in Organic Chemistry supervised by Professor Sir J E Baldwin (1987-1990)

Post doctoral research at Columbia University, New York, supervised by Professor Gilbert Stork (1990-1992)

University Lecturer and Tutorial Fellow in Organic Chemistry, Oxford (1992 to date)

Undergraduate Teaching

I cover all aspects of the Organic Chemistry component of Oxford's four year MChem degree

Research Interests

Natural product synthesis and synthetic methodology

Our group carries out research into the chemical synthesis of certain natural products selected because they present unique problems that we think we can solve in unusual and efficient ways. Our goals are to discover new chemistry and to gain deeper insights into reactivity and mechanism. Recent research focuses on harnessing Nature’s catalysts – specifically cytochrome P450 enzymes – to perform transformations not possible by chemical reagents such as the direct conversion of C–H to C–OH with high selectivity.

Publications Include

1. 1) Org. Lett. 2024, 26, 1556. Routes to Advanced Intermediates in the Synthesis of Tetracarbocyclic Sesquiterpenoids Daphnenoid A and Artatrovirenols A and B
2. 2) J. Am. Chem. Soc. 2023, 145, 27767. Selective P450_BM3 Hydroxylation of Cyclobutylamine and Bicyclo[1.1.1]pentylamine Derivatives: Underpinning Synthetic Chemistry for Drug Discovery
3. 3) Org. Lett. 2023, 25, 7507. Two Total Syntheses of Trigoxyphins K and L
4. 4) Molecules 2023, 28, 3900. An Enantiospecific Synthesis of 5-epi-α-Bulnesene
5. 5) Nat. Synth. 2022, 1, 921. Accelerated Enzyme Evolution for Targeted C–H Oxidation in Cyclic Amines 
6. 6) Nat. Synth. 2022, 1, 936. Enantioselective Oxidation of Unactivated C–H Bonds in Cyclic Amines by Iterative Docking-Guided Mutagenesis of P450_BM3 (CYP102A1)

Email address

[email protected]

Links

Jeremy Robertson